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KMID : 1101720140180040347
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Physical Activity and Nutrition
2014 Volume.18 No. 4 p.347 ~ p.353
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The ACTN3 R577X variant in sprint and strength performance
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Kim Hyeoi-Jin
Song Keon-Hyoung
Kim Chul-Hyun
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Abstract
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[Purpose] The aim of this study is to examine the association between the distribution of ACTN3 genotypes and alleles in power, speed, and strength-oriented athletics.
[Methods] ACTN3 genotyping was carried out for a total of 975 Korean participants: top-level sprinters (n = 58), top-level strength athletes (n = 63), and healthy controls (n = 854).
[Results] Genetic associations were evaluated by chi-squire test or Fisher’s exact test. In the power-oriented group composed of sprinters and strength athletes, the frequency of the XX genotype was significantly underrepresented (11.6%) in comparison to its representation in the control group (11.6% versus 19.1%, P < 0.05). When the power-oriented group was divided into strength-oriented and speed-oriented groups, no significant difference in the ACTN3 XX genotype was found between the strength-oriented athletes and the controls (15.9% versus 19.1%, P < 0.262). Only the speed-oriented athletes showed significant differences in the frequency distributions of the ACTN3 XX genotype (6.9% versus 19.1%, P < 0.05) from that of the controls.
[Conclusion] The ACTN3 genotype seems to mainly affect sports performance and especially speed.
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KEYWORD
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α-actinin-3, human performance, population genetics, fast-twitch muscle fibers, contractile property
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